IGF-1 & Bodybuilding – IGF-1 LR3 Side Effects
IGF-1 LR3, Long R3 IGF-1, IGF-1- Insulin-like Growth Factor – is an experimental drug that represents the next generation in performance enhancing in bodybuilding athletes. This peptide hormone also has the promise of becoming the ultimate fountain of youth.
As the world has finally caught on to the fact that world-class athletes from all sports have been using steroids and other performance enhancing drugs (PEDs), the athletes themselves have moved on to the next generation of substances.
Long R3 IGF-1 is mainly secreted by the liver as a result of stimulation by Human Growth Hormone (HGH). Almost every cell in the human body is affected by IGF-I, especially cells in muscle, cartilage, bone, liver, kidney, nerves, skin, and lungs. In addition to the insulin-like effects, IGF-I can also regulate cell growth and development, especially in nerve cells, as well as cellular DNA synthesis.
IGF-1 LR3 Benefits:
- Stimulates muscle growth and has been shown to benefit the heart (a muscle).
- Encourages the absorption of Chondroitin Sulfate and Glucosamine Sulfate (also found in Velvet Antler).
- Regenerates nerve tissue
- Helps burn fat, increase protein transport into cells, and reduce protein breakdown
- Improves the production of white blood cells
- Decreases LDL Cholesterol
IGF-1 LR3 is a hormone just like HGH, but IGF-1 is the most important growth factor that the body produces. IGF-1 is much more powerful than HGH.
Currently the license to conduct human trials using IGF-1 is held by biopharmaceutical company Tercica and is limited to the study of children suffering from growth failure due to IGF-1 deficiency.
Even though the human study of IGF-1 LR3 is extremely narrow and limited to kids, the fact that this substance has been studied on rats and humans and is in the hands of people in labs means that the genie is out of the bottle.
IGF-1 has been used in lab studies since at least the late 1990s; so many people have had access to this drug for quite a long time. And there are people with tons of money who would love to get their hands on this stuff.
IGF-1 LR3 has produced some amazing results in lab rats. Now before you get all over me for talking about success with lab rats, you have to realize that this success with lab rats did lead to the human trials. And the results of the tests with lab rats have been astounding.
The benefits from IGF-1 are so astounding – and offer such promise to humans – that back in 2002, H. Lee Sweeney, Ph.D., Professor and Chairman of Physiology at the University of Pennsylvania and a recognized expert on the subject of the genetic enhancement of skeletal muscle, spoke to the World Anti-Doping Association with regard to the muscle building and regenerating properties of IGF-1.
In 2002, speaking before The President’s Counsel On Bioethics, Dr. Sweeney was of the opinion that the advent of genetically engineered athletes was not imminent and that studies needed to be done in order to determine the safety and long-term effects of IGF-1.
To think that using IGF-1 LR3 to build a better athlete is off in the future, and that this hormone won’t be used until human safety studies can be done, is to ignore the history of how these drugs have been used by athletes. Dr. Sweeney’s position is one of wishful thinking. And I mean no offense to the doctor in any way.
Going back to the HGH situation, bodybuilders were using this hormone in the mid-’80s well before people totally understood how and what this drug really could do. To this day there are many unknowns that are associated with the use of HGH, including the debate as to its safety, yet the use of this hormone is widespread in bodybuilding, in real sports, and in the general population.
Here are some of the reasons why IGF-1 will revolutionize the world of performance enhancing substances, and why athletes will risk – are risking – their health to use it.
IGF-1 has been shown to increase the rate and extent of muscle repair after injury and increase the rate of muscle growth from training. And not only are existing muscle fibers repaired quicker, IGF-1 is responsible for hyperplasia, which is an increase in the amount of muscle fibers.
Hyperplasia is the Holy Grail of performance enhancing benefits, and occurs when muscle fibers actually split, therefore creating more muscle fibers. Hypertrophy is simply an increase in the size of the existing muscle cells, and occurs from weight training and from steroid use. Hyperplasia plus hypertrophy equals a new breed of amazing athlete.
But wait, there’s more:
Rats that were given IGF-1 and did nothing were bigger and stronger than rats that weren’t given IGF-1 but exercised. And I’ll bet you guessed that rats that were given IGF-1 and exercised were the biggest, strongest rats in the house. The positive effects of IGF-1 on the rats continued for months after the rats stopped getting the supplemental hormone, whereas the exercising rats immediately lost size and strength as soon as they stopped exercising.
In another study the muscle fibers of 27-month old rats – old age for rats – that were given IGF-1 during middle age, exhibited no deterioration of muscle fibers that indicate the classic and inevitable signs of aging. These rats did not lose any fast twitch muscle fibers – the fibers responsible for power and speed – and had the same speed and power output that they had when they were six months of age.
To quote Dr. Sweeney, “So we were able to conclude that IGF-1 could prevent all of the hallmarks of age-related atrophy and loss of skeletal muscle function in mammalian aging, at least based on the rodent model, and now we’re hoping to pursue this in larger animal models.”
Dr. Sweeney also says that IGF-1 could be used as an instant muscle builder for members of the general population.
And here’s the final and most compelling reason why IGF-1 is being used right now, and why the demand for this hormone will increase exponentially as time goes by: IGF-1 is undetectable by both blood and urine testing. Because IGF-1 can be injected directly into the muscle, it never enters the blood stream. Therefore, a muscle biopsy is the only way to determine if a person has used IGF-1. And the anti-doping forces will never, ever be allowed to take muscle biopsies from athletes.
In a January 18th, 2004 New York Times Magazine cover story by Michael Sokolove, Dr. Sweeney says (page 30) that after presenting his IGF-1 info at an American Society for Cell Biology conference he was contacted by a high school football coach from Pennsylvania who wanted Dr. Sweeney to treat his entire team. Do you think by now world-class athletes – with world-class money – are interested in IGF-1?
Included in this article (page 28) were additional details with regard to the results of studies, in which rodents given IGF-1 before birth and at four weeks of age experienced a 35% increase in strength in targeted muscles, did not lose any size and strength as they aged and did not lose any of these gains when they stopped training.
Later on in the article Dr. Sweeney admits that athletes could already be using IGF-1. Elisabeth Barton, an assistant professor who was involved with Dr. Sweeney’s studies, says that creating a human athlete along the lines of these super mice “is easy.”
She goes on to explain, “It’s a routine method that’s published. Anyone who can clone a gene and work with cells could do it. It’s not a mystery.”
Dr. Sweeney added that there’s no limit to what can be done with IGF-1 and gene therapy with regards to building a better athlete. To make a sprinter faster Sweeney said, “I’d put the whole leg on bypass. I would put (IGF-1) in through the blood. It would be more efficient than injections (directly into the muscle), which you would need a lot of because you’re dealing with large muscles. But this is nothing a vascular surgeon couldn’t do.”
So to recap, IGF-1 provides almost permanent muscle-creating, muscle-repairing, and anti-aging benefits and is totally undetectable. Do you think athletes are chomping at the bit to get their hands on this stuff?
The legitimate scientific world is following the proper protocols with regards to IGF-1, but the underground world is not bound by the same rules. Legitimate science – rightly so – is nowhere near ready to allow “us” to start using this stuff. But this isn’t the point.
The point is that there is a substance out there that scientists are cautiously touting as an instant muscle builder and a fountain of youth, and for some people this is all that they need to hear. These people aren’t going to wait – haven’t waited – for legit science to bless the use of IGF-1 LR3 for human consumption before they go out and inject themselves with it. Adverse side affects? Please.
In 2004 the leading experts on the subject admitted that this gene therapy could already be in use, and that the technology and knowledge is such that the process to deliver it isn’t complicated. Two and a half years later this circle of knowledge, and use, is that much larger.
Knowing how HGH was purloined by people who were too impatient to wait for legit science to do it’s thing, bodybuilders and real athletes did what they had to do to get it and use it, danger be damned. There’s no reason to think that the same situation isn’t occurring right now.
Bodybuilding web sites, bulletin boards, and chat rooms are awash with discussions about IGF-1, what it can do, how to use it, and what drugs to stack with it. There’s talk that underground labs are synthesizing IGF-1, HGH, and a host of other substances.
According to Chemical Muscle Enhancement, a well-known underground PED guidebook written by Internet steroid guru L. Rea and available via download or through Amazon, IGF-1 has even been altered to increase its effectiveness, making IGF-1 ten times more potent (pages 134-136 of Chemical Muscle Enhancement). Several websites make reference to this altered form of IGF-1 – known as DES (1-3) IGF-1. This version of IGF-1, Insulin-like Growth Factor is also refereed to as Lr3IGF-1 (Note: Lr3IGF-1 is 2-3x more potent than regular IGF-1).
IGF-1 is being synthesized and altered in underground labs and is being sold on the black market. Bodybuilders are using IGF-1 and it is illogical and naive to think that some athletes at the highest level of sport are not using IGF-1 right now. People who you’ve probably never even heard of are using it just as there are well-known athletes who have already benefited from the use of IGF-1.
People did crazy things to get their hands on HGH 20 years ago, did crazy things to get their hands on whatever the next-generation drug was 30 years ago, and it’s no different today.
While in some sense the public has finally caught on to “steroids,” the high-tech, high-minded athletes have moved on, light years ahead of what the public can conceive of and comprehend. “Steroids” is the Model-T Ford; IGF-1 is the USS Enterprise or the Millennium Falcon.
With each advance in the field of PEDs the underground has been responsible for the spread of knowledge and supply of these drugs. Advances in technology and today’s free flow of information have made it possible for underground labs to synthesize, alter, and deliver into the body drugs of all types.
With money, fame, and even a kind of immortality involved, there’s no telling what some people will do. The mindset of the PED user is that IGF-1 can deliver all three of these.
The use of PEDs up until this point has pretty much been a black and white issue, but with this next generation of substances now available the debate will get much more complicated. PEDs are NOT going to be eradicated, their use will become more widespread as the benefits that they provide become more and more attractive to potential users.
Tips for maximizing your Insulin-like growth factor, IGF-1 LR3:
If you are not using ZMA currently, you should start it up before starting the IGF-1. Zinc plays a very crucial role in enzyme activation of IGF-1. It also increases blood plasma levels of total and free IGF-1. A deficiency actually hinders IGF-1 formation.
Since IGF-1 LR3 is such a new peptide, there are no long term studies about the IGF-1 side effects.
October 4th, 2007 at 3:34 am
hi guys! can i now more about how can i use igf1?thank you
October 6th, 2007 at 1:13 pm
I have a friend who is quadraplegic and has always been a bodybuilder. he has done a lot of research on IGF-1 and has asked me to find this so he can, at least, be able to keep some of his muscle mass. I appreciate your help. thanks, nikki
October 19th, 2007 at 9:51 am
This seems to be a great alternative to the traditional ‘drugs’ we’ve been taking. what are the effects on high blood pressure kidneys and liver.
Kind regards
Rudy
Please tell me if there is any known side effects
October 19th, 2007 at 6:44 pm
IGF-1 LR3 is such a new peptide there is little long term empirical data on its effects. Remember IGF-1 is the anabolic agent of HGH so you tend to see results in weeks, as apposed, to the six months it takes HGH to really take effect.
IGF-1 is a research peptide, it hasn’t been approved by the FDA for use as a pharmaceutical and it is currently being used and researched for nerve tissue repair, possible burn victims, as a possible aid in muscle wasting for AIDS patients, and also insulin resistance.
November 6th, 2007 at 3:50 pm
Will Igf activate cancer cells? will it build more muscle where i don’t want to such as the thighs? in stead of chest and upper arms even though i don’t get to do much lifting at all, i need to increase my strength? also would it make the face any bigger? i want the face to slimmer/younger. im 35 yrs of age what else comes close to to as potent and powerfull, thus safe? is it organic?
i need to know what the price of the products are and would cost.
November 7th, 2007 at 2:52 am
IGF-1 is a naturally produced growth factor that is expressed in a number of tissues in the body. With regards to human muscle hypertrophy, work is currently being done to understand the biochemical pathways that IGF-1 activates. In Skeletal muscle, IGF-1 enhances muscle satellite cell proliferation and differentiation which MAY lead to enhanced tissue repair and contribute myonuclei to exsisting muscle fibres. I caution the notion of hyperplasia. There is no conclusive data to indicate that hyperplasia is induced by IGF-1.
In cell cultures (dish full of muscle precursor cells call myoblasts) the ectopic expression of IGF-1 will induce differentiation of myoblasts into myotubes (muscle fibers). this will not happen in the body, however these increased myonucei will fuse to exsisting fibers, making them larger.
Bottom Line, the benifits and costs of IGF-1 use are far from known yet.
cheers,
April 8th, 2008 at 10:22 pm
You might want to start doing some research on hypoglycemia brought on after taking IGF. My son is curently having problems with this right now. Symptoms include dizziness, panic attacks, depression, tremors, feeling close to losing both control and consciousness. One trip to the ER and another to a doctor’s office have resulted in no concrete answers. He has a friend who reported the same symptoms. The friend made 4 trips to the ER because he felt like he was going to either pass out or die. The friend, too, had these symptoms come on after getting off IGF. Two words…..be careful.
May 9th, 2008 at 9:11 pm
In responce to Mom,
This is not a substance to take lightly. This is a very powerful stubstance and affects your insulin levels. You need to keep an eye on your blood sugar levels while on and coming off of IGF1. If not, you could easily go hypo and pass out or feel like you are going to pass out. If the user has not studied this drug and understand how it works i would not recommend using it.
May 27th, 2008 at 4:08 am
“IGF-I has been identified as a key factor in cancer.”
(Hankinson. The Lancet, vol. 351. May 9, 1998)
The IGF signaling pathway appears to play a crucial role in cancer. (Velcheti V, Govindan R (2006). “Insulin-like growth factor and lung cancer”. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1 (7): 607-10)
May 27th, 2008 at 1:55 pm
We continue to see conflicting data all the time on this issue. According to the below data, from the National Cancer Institute, IGF’s have the ability to promote as well as suppress certain types of cancers cells. That is why it is imperative you stay under the supervision of a good hormone doctor.
IGF-I levels in human tissue causes many of the degenerative changes associated with aging. We believe it is aging which is greater catalyst for Cancer. If IGF-1 caused cancer it would run rampant in kids. You don’t really see that. IGF-1 could cause cancer to grow faster; however, it does not give one cancer if it is not already present.
Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression
J Natl Cancer Inst 2000; 92: 1472-1489 20sep00
http://www.mindfully.org/Health/IGF-I-Cancer-Development.htm
There is plenty of evidence that IGF-1 extends the lives of men.
June 12th, 2008 at 7:07 pm
Does IGF-1 have the same overall body growth results that HGH has, such as bone and organ growth?
June 13th, 2008 at 8:04 am
IF you are a grown man, IGF or HGH does not cause bone or organs to grow at normal doses. You must be under the direct supervision of a good hormone doctor to even consider these peptides. They are really strong.
June 18th, 2008 at 5:30 pm
I am just getting into the IGF-1 reasearch. Is the
IGF-1(the spray)found in stores such as GNC the same product? Doesn’t seem like it from the info I gather. How is that IGF-1 different than what we are talking about in the article?
June 19th, 2008 at 11:45 pm
Travis over the counter hGH and IGF-1 products are bogus. Most of these peptides need to be injected and prescribed by a hormone doctor.
September 30th, 2008 at 11:13 pm
They say milk drinking increses IGF-1 levels. I wonder if that’s true, and what’s the significance for body building benefit as well as (prostate) cancer risk. I also wonder if my home grown raw goat’s milk, cultured into kefir or fil mjolk has the same effect on IGF-1 as cow milk. I heard a rumor (from a doctor) that fermenting milk inactivates certain growth factors in same.
October 15th, 2008 at 3:48 pm
man this IGF is sum crazy shiznit,but I think its really just a small aspect of what all the pro bodybuilders use.I read somewhere that even prototype mystatin blockers might be used in recent years ,due to the dramatic upcoming of bodybuilders who achieved freakish size in just 4-5 years time.Might be something else though.
What I dont get ,is that with all these atlethic benefits of these advanced ergogenics ,that they seemingly cant get put to good use,and yes I know they have to be tested thouroughly ,I dont see these top athletes dropping dead by the minute though..
October 22nd, 2008 at 3:43 pm
Keep in mind, as great as this peptide sounds, in all reality, dedication to the lifestyle of bodybuilding is the only way to see results from this product. I know that for fact!
And even if you people looking for this product find it, you better hope you have HUMAN LR3IGF-1. The black market is not regulated. Tests were already done on what has infiltrated the black market, and it is not surprising to say, Rat LR3IGF-1 was in the vials. And yes, this is the product that people have been buying for years in the underground community.
January 17th, 2009 at 1:23 pm
Generally I do not post on blogs, but I would like to say that this post really forced me to do so, really useful information.
January 23rd, 2009 at 7:21 pm
Does the antler velvet spray that you get in organic food stores work? This is what it says,”IGF-1 [Structural] (insulin-like growth factor 1) is a metabolite of human growth hormone. Scientists have discovered that an extract of the velvet on the antlers of a particular species of deer (Cervi parvum cornu) provides IGF-1 and all of its benefits.
Researchers have found that deer antler velvet contains eight known growth factors, prostaglandins, nerve-protective fatty acids, prohormones, amino acids and components of cartilage (including glucosamine, chondroitin sulfate, collagen type I, collagen type II and minerals).”
January 23rd, 2009 at 7:31 pm
I would say this velvet spray is a snake oil!
January 28th, 2009 at 10:57 pm
im a married man and 27yrs old what kind of side effects should i expect? will my testicles and penis shrink or will i get acne, become aggressive?what about cancer[prostate; i an african american]also are there anyother known side effects?
January 28th, 2009 at 11:54 pm
You should seek this kind of advice from a hormone doctor.
February 17th, 2009 at 8:16 am
IGF1 belongs to the peptide family of substances identified as growth factors. It is a highly anabolic hormone released in the liver as well as in peripheral tissues such as skeletal muscle. In the body, IGF-1 is released in response to the presence of Growth Hormone (GH). After intense resistance training, the body experiences a surge in GH and IGF, and this is one way that new muscle is built. Although GH is considered to be highly anabolic, in actuality, IGF-1 is suspected to be responsible for the primary anabolic activities of GH.
IGF-1 builds new muscle tissue by promoting nitrogen retention and protein synthesis. This causes the growth of muscles through both hyperplasia (which is an increase in number of muscle cells) and mitogenesis (which is the actual growth of new muscle fibers). Thus IGF-1 not only makes muscle fibers bigger, it makes more of them as well!
IGF-1’s effects are not limited to building new muscle, however. It has a potent effect on lipid (fat) metabolism, and helps the body burn fat at a significantly elevated rate. In addition, IGF-1 is both a neuroprotector and neuropromotor, which improves mental functions such as reflexes, memory, and learning ability. IGF is also important for production of connective tissue and insuring proper bone density.
Although IGF-1 is very potent at building muscle and burning fat, the Lr3 IGF-1 version is roughly 2-3x as powerful.
Lr3IGF-1 (Long R3 Insulin-like Growth Factor-I or Long R3IGF-I) is an 83 amino acid analog of human IGF-I actually comprising the complete human IGF-1 sequence but with the substitution of an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus. This makes Long R3IGF-I significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body.
April 16th, 2009 at 5:22 am
My wife just had a shot of IGF-1 LR3. She experienced everything MOM mentioned above. Make sure you keep some food in your system every 3 hours or so, to balance the blood sugar. She was also taking HGH shots 1IU four days a week as well as testosterone cream, progesterone and biest. Her Dr. gave the injection but failed to mention potential side effects even though he knows she has a blood sugar issue , which is improving with the hgh, by the way.
The shot was given directly into her post surgical knee X-2, 2007 and 2008. Her pain went away for two days after the shot. The next day after the shot she woke up feeling like she dropped a lot of body fat and felt superstrong.
I suggest keeping a journal of the effects of the substance you take and dosages. Be safe! Be aware!
April 27th, 2009 at 4:24 pm
You made some good points there. I did a search on the topic and found most people will agree with your blog.
August 22nd, 2009 at 1:04 pm
Note: Lr3IGF-1 is 2-3x more potent than regular IGF-1).
It’s not really that it’s more potent, The difference between the original version “IFG-1″ and the newer improved version “IGF-1R3″ is that the new version has a longer half-life and thusly no need inject it several times a day as you had to do with the original IGF-1. Instead of minutes, you now have the IGF-1r3 staying active for hours.
Very nicely pieced together article though.. I enjoyed reading it
December 14th, 2009 at 12:11 am
Would this really help an injury recover faster, such as tendinitis of the shoulder?
December 15th, 2009 at 5:12 pm
We think so; however, that would be a question for your doctor.
February 5th, 2010 at 7:19 pm
I used a two week cycle one week off and two weeks on and got really sick then did the cycle again about a month later then got really sick again but geez I could run and jump like crazy!!! I do work at a dirty casino that has a novo virus going around right now so i don’t know if IGF-1 weakend my immune system of not?
March 29th, 2010 at 12:33 am
I have a question to TheSaga or anybody who can help me.
I am endurance athlete and I’ve been in my sport for 17 years now.I’ve been doing my research on IGF for quite a while and I’m considering taking it, but a couple things are unclear for me.
I understand that one can take it on his own and it look s really safe. However TheSaga mentioned that a supervision of a hormone doctor is a good thing. Do all bodybuilders have that or it’s just an extra.
I never had insulin level problems, but Mom’s post made me a little nervous, do I have to monitor my insulin levels if I’m taking IGF or just make it sure to eat frequently?
Thank you!
March 29th, 2010 at 2:14 pm
@Athlete no.4141
IGF is a very powerful compound and that is why we recommend you work with a hormone doctor. Otherwise you are gambling with your life.
April 8th, 2010 at 7:29 am
I am purchasing a kit of Long R3 IGF-1 through a pharma comapany in China (by the way I am there too) and I was just wondering if anyone had info or tips on it. The product is called IGTROPIN and it seems to be the best on circulation right now.
I never tried IGF-1 (nor HGH) before and although I have never had problems with insulin levels or blood pressure, I must confess that I am a bit concerned about it. I live a regular life, eating every 3 hours or so (clean carbs, meat, albumen, fresh salads, olivoil, tofu and so on), no smoker, no alcohol, constant physical activity every day (BB, Swimming, MMA)and I feel like I need a chemical support (I am 33 and I can’t say I feel like 5 years ago anymore..)right now (it’s been years actually )since I can see my body falling apart… accumulating fat too easily and not recovering from workout as supposed to.
I’ll appreciate any info given by someone with an actual experience using this compound.
I mostly need tips on :
-how to store it (what temperature.. would a regular fridge be ok?)
-how long can it stay before administration (after being diluted, I am buying the lyphosized form)
- When is the best time to have it administered (early morning, right after workout.. once twice a day)
-How to take the shots(peritoneal, subcutaneous..above the belly button, lower..)
- Would be 20mcg /daily sufficient to have some results ?(and by results I don’t mean getting huge but just gain some quality ..)
Please note that not being in my own country right now gives me zero chances to get to a hormone doctor (endocrinologist)for a consultation.
Cheers
April 8th, 2010 at 11:13 am
@Mel
Check out the below two links for more info. Google will also help you answer your questions.
http://www.thesage-speaks.com/how-to-mix-igf-1-long-r3/
http://www.thesage-speaks.com/igf-1-insulin-like-gowth-factor-explained/
April 29th, 2010 at 1:02 am
IGTROPIN comes in 10 100mcgs vials> only reconstitute what you need ie one vial at a time> put the rest in the freezer and the vial you are currently using in the fridge> and it will keep fine>
Please do research and not just blindly repeat info as fact, IGTROPIN I believe is made to have a PH correction in the binder so using AA can actually ruin most of the active IGF in it, so you might want to use BA or BW to reconstitute it.
You should always ask the supplier about the binders in it
Since your vials are 100 mcgs each bariostatic water (BW) will work fine either way(as you will use the vial up before the IGF-1 degrades too much> also AA is acetic acid which when injected into muscle will damage the muscle tissue.
My advice is to get as much info as you can
I do not mean to knock the OP of this thread as this is still a great resource, but I see too many sites and post saying to use only AA and that is not always the case.
April 30th, 2010 at 12:51 pm
Thanks for your reply. I have already started with 20mcg twice a day (20 morning+20pwo). Doesn’t seem to do much though. I feel a bit sleepy but not hungry. I administer the doses subcutaneously on the peritoneum (left and right sides)..is that OK? Or better intramuscularly?
I diluted my compound with sterile water (I already new that AA would have ruined it but not because my provider told so… they know shit about it they are just sellers ..), 2ml of it. I do keep though all in the fridge (lyphosized form can stay even at room temp for more than 6 months if not diluted ..so fridge would be more than fine.. besides, I feel tem in the freezer would be too low..).
May 1st, 2010 at 10:35 am
Ahh I am about a week into a course of IGF-1 r-3 I am using receptor grade. My advice is to up the dose a bit. Also I really have not seen anyone post this anywhere except in a med report but most people do not realize the amount of time IGF-1 stays active in your system. I see half lifes listed between 4-10 hours this half life though is of unbound IGF-1 in the blood stream, here is the interesting part is that once bound to a receptor the igf-1 will be active for another 72 hours.
As for your question I use IGF-1 subQ, as IGF-1 is systemic (i have seen no science that IM local effects on the muscle injected actually work) As mentioned I recommend that you up the dose to about 80mcgs and take it 2 days on and an off day on the third day. I have personally tried doses as high as 140mcgs daily but at that dose the sides were a bit too much as I actually went hypoglycemic at that dose. IMHO and from talking to others the higher the dose the more effective IGF-1 seems to work. Although I am guessing that as long as you are feeling some sides from it that what you have is real and will still give you benefits. Either IM or subQ injections are fine, just do what you are comfortable with.
With IGF-1 r-3 the biggest mistake I have seen people make is that they do not take in enough protein, Here is the diet protocol I use when on IGF or even if I am just cutting in general.
- Workout at least 3 times a week with weights.
- Eat at least 1g protein / lb lean body mass.
- Reduce calories to maintenance levels or about 500 cals below maintenance.
None of those are really all that hard to follow but will give you the optimum results.
Here is kinda a reference chart for those that may need it, if you do not know your maintenance cals you can use a site called Fitday they have free logs there with built in tools to track everything for you.
This chart follows a 40/40/20 ratio
1600 calories: 160g protein, 160g carbs, 35g fat
1800 calories: 180g protein, 180g carbs, 40g fat
2250 calories: 225g protein, 225g carbs, 50g fat
2700 calories: 270g protein, 270g carbs, 60g fat
3150 calories: 315g protein, 315g carbs, 70g fat
This is just to give you a guideline, just customize it to your needs< if you lose or are not gaining the amount of muscle you want up the protein, if you gain or are not losing enough fat then lower the carbs and fat to meet your needs.
May 1st, 2010 at 4:36 pm
Thanks for the accurate reply mate.
I’ll try to follow your diet (it might be the key.. I got probably too many cals right now..prot seem to be enough though..). I am working out two days in a row and 1 off. Same with IGF (though I’d like to inject 20 mcg only in the morning on my day off too…). I’ll finish this vial at the same dose I am now and start the next at 25mcg twice a day. See what happens.
By the way, how many eggs (medium size, boiled, only white eaten) do make 35g of prot? 7? And how can I measure 10g of whey prot (absolute powder, no flavour no adds.. NZ product..)? would a large spoon be ok for 10g? Do you have any tips? ..Unfortunately I do not have an electronic scales..Silly I know.. but I live in China now..
May 5th, 2010 at 3:23 pm
do the pill forms of igf-1 work? i ordered a product called pure solutions igf-1 extreme?
May 5th, 2010 at 11:37 pm
@jr
All oral igf-1 stuff we have looked at is junk.
July 13th, 2010 at 3:02 pm
Hey there.
I am a competitive BB and have been using various anabolics on and off for the past 5 years. I have now decided to experiment with peptides and have purchased 4,000mcg’s of IGF-1 1LR3 and 3,000iu’s of HGH. As a bodybuilder my goals are lean muscle mass and fat loss.
My questions that are in need of clarification are:
1. Should I run IGF alone or together with GH?
2. IGF administarion – Intramuscular, subcutaneous or into bloodstream?
3. Is there a need to run T3 and/or T4 at the same time?
4. Is a daily dose of 50mcg over 5 weeks sufficient?
5. Will the use of Insulin benefit the IGF cycle in terms of its half-life.
Thank you – I look forward to your thoughts.
August 11th, 2010 at 7:47 pm
ive been on igf1 lr3 and igf3 lr3 for 3 wks now and a 10day cycle of hexcelerin,, injectibles, i work out 5 dayz a week for about an hour a day, and on the weekends do mild work outs on my mid section and legs as i dont have to much problem with them..
and ive seen awesome gains so far.. i got a 50 day cycle cant wait to c myself at the end of it..
im not stackin it with nothing else other than eating 6x a day, multi vit. with my protien shakes and a carb load shake right after i work out and 15min before i inject.
ive had blood work done last week and everything seems fine other than alil low glucose level but sugar and pressure are right on point,, i did bloodwork for cancers before i started and was clean, ill check again after my cycle and let u know if anything has changed lol ,, i havent gotten any side effects as of yet..
October 22nd, 2010 at 5:42 pm
hey guys, i heard alot about IGF 1 and i fink it shud be pretty effective , i just wana know does it have any side effect on heart … specially if someone have a septal atrial defect. cos i heard that IGF 1 is pretty beneficial for heart.
thnx
October 31st, 2010 at 12:09 pm
hi guys! do you know any bad side effect using IGF-1 L3. can i still drink liquior while taking this drug
Thanks!
March 2nd, 2011 at 4:32 am
I have question
IGF-1 is a hormone ?…because i thought it is amino acid, and i thought IGH is hormone !!! (insulin like growth hormone)
and another question is i am 18 yrs, and working in bodybuilding for almost 3 yrs i want to start a cycle of IGF-1 LR3.. do you think its too early for me ?…
March 2nd, 2011 at 10:26 am
@Navid – “IGF-1 is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure.”
We recommend you speak to a hormone doctor.
March 29th, 2011 at 3:34 pm
sage – had chronic tendinopathy in both shoulders for almost 2 yrs. conservative treatments such as Physio havnt been effective. Obviously its not an inflammatory condition. does Igf or HGH help to your knowledge?
March 29th, 2011 at 10:27 pm
@Mark – we have heard anecdotal reports of IGF being used to regenerate connective tissue. Speak to your hormone doctor and get their opinion.
June 17th, 2011 at 7:32 pm
Igf long r3 is not secreted by the liver. Long r3 has 13 additional protiens in its peptide chain attached at the third protein in its peptide sequence.
September 23rd, 2011 at 1:15 pm
The most interesting and potent effect IGF has on the human body is its ability to cause hyperplasia, which is an actual splitting of cells. Hypertrophy is what occurs during weight training and steroid use, it is simply an increase in the size of muscle cells. See, after puberty you have a set number of muscle cells, and all you are able to do is increase the size of these muscle cells, you don’t actually gain more. But, with IGF use you are able to cause this hyperplasia which actually increases the number of muscle cells present in the tissue, and through weight training and steroid usage you are able to mature these new cells, in other words make them grow and become stronger. So in a way IGF can actually change your genetic capabilities in terms of muscle tissue and cell count. IGF proliferates and differentiates the number of types of cells present. At a genetic level it has the potential to alter an individuals capacity to build superior muscle density and size.
April 18th, 2012 at 8:28 pm
Can igf-1 be used to repair a partially torn labrum by anychance any help would be much appreciated thank you
June 7th, 2012 at 3:21 pm
Does it cost pimples? I tried other things before and it cost me to breakout bad so I’m worry about taking this
June 7th, 2012 at 3:24 pm
@John – we have not heard any reports of hgh causing pimples.